Total synthesis of (+/-)-chartelline C.
نویسندگان
چکیده
The first total synthesis of (+/-)-chartelline C in a concise 10-step sequence is reported. Highlights of the completion of this decades-old puzzle include (1) chemo- and position-selective installation of the heteroaromatic halogens, (2) halogen-sparing monoreduction of an alkyne linker, (3) a simple strategy for placement of the sensitive beta-chloroenamide, (4) an unusually facile thermolysis of a vinyl carboxylic acid, and (5) a powerful ring contraction whose potential utility in heterocyclic chemistry merits further investigation.
منابع مشابه
Synthetic studies and biosynthetic speculation on marine alkaloid chartelline.
Synthetic studies and biosynthetic speculation on chartelline inspired by an unexpected reaction are described.
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 128 43 شماره
صفحات -
تاریخ انتشار 2006